| Autor: |
HÖCKERFELT, U., HANSSON, M., GULBENKIAN, S., FRANZÉN, L., HENRIKSSON, R., FORSGREN, S. |
| Zdroj: |
Annals of the New York Academy of Sciences; December 1998, Vol. 865 Issue: 1 p344-352, 9p |
| Abstrakt: |
Rats were given radiotherapy (total dose 30 Gy) over the abdomen. Seven days later specimens of the duodenum were prepared for in vitroreceptor autoradiography using the radioligand [125I]VIP. The autoradiograms were quantitatively analyzed using a computer system. Histological examination revealed that a very marked reorganization of the mucosa had occurred in response to irradiation. Using receptor autoradiography, we found [125I]VIP-specific binding sites in the reorganizing mucosa, except where denudation had occurred. Such binding sites also occurred in the smooth muscle layer of the duodenal wall. The observations suggest that VIP has profound effects in radiation-induced enteropathy. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Plný text