| Autor: |
ANGELUCCI, EMANUELE, MURETTO, PIETRO, LUCARELLI, GUIDO, RIPALTI, MARTA, BARONCIANI, DONATELLA, ERER, BUKET, GALIMBERTI, MARIA, ANNIBALI, MAURO, GIARDINI, CLAUDIO, GAZIEV, DJAVID, RAPA, SIMONA, POLCHI, PAOLA |
| Zdroj: |
Annals of the New York Academy of Sciences; June 1998, Vol. 850 Issue: 1 p288-293, 6p |
| Abstrakt: |
After successful marrow transplantation (BMT) iron overload remains an important cause of morbidity in Thalassemia. After BMT, patients have normal erythropoiesis capable of producing a hyperplastic response to phlebotomy so that this procedure can be contemplated as a method of mobilizing iron from overloaded tissues. Forty-one patients (mean age 16±2.9 years) with prolonged follow-up (range 2-7 years) after BMT were submitted to a moderate intensity phlebotomy program (6 mlkg blood withdrawal at 14-day intervals) to reduce iron overload. Values are expressed as mean ± SD or as median with a range (25th-75thpercentile). Serum ferritin decreased from 2,587 (2,129-4,817) to 280 (132-920) ?gl (p< 0.0001), total transferrin increased from 2.34±0.37 to 2.9±0.66 gl (p 0.0001), transferrin saturation decreased from 90±14 to 39±34 (p< 0.0001). Liver iron concentration evaluated on liver biopsy specimens decreased from 20.8 (15.5-28.1) to 3 (0.9-14.6) mgg dry weight (p< 0.0001). Alanine amino-transaminase from 5.2±3.4 to 1.6±1.2 (p< 0.0001) times the upper level of normality. The histological grading for chronic hepatitis (Histology Activity Index) decreased from 4.2±2.4 to 2.3±1.8 (p< 0.0001). Phlebotomy is a safe, efficient, and widely applicable method to decrease iron overload in "ex-thalassemic." |
| Databáze: |
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