| Autor: |
GAMES, DORA, BARD, FREDERIQUE, GRAJEDA, HENRY, GUIDO, TERRY, KHAN, KAREN, SORIANO, FERDIE, VASQUEZ, NICKI, WEHNER, NANCY, JOHNSON-WOOD, KELLY, YEDNOCK, TED, SEUBERT, PETER, SCHENK, DALE |
| Zdroj: |
Annals of the New York Academy of Sciences; December 2000, Vol. 920 Issue: 1 p274-284, 11p |
| Abstrakt: |
In AD certain brain structures contain a pathological density of A? protein deposited into plaques. The effect of genetic mutations found in early onset AD patients was an overproduction of A?42, strongly suggesting that overproduction of A?42is associated with AD. We hypothesized that an immunological response to A?42might alter its turnover and metabolism. Young PDAPP transgenic mice were immunized with A?1-42, which essentially prevented amyloid deposition; astrocytosis was dramatically reduced and there was reduction in A?-induced inflammatory response as well. A?1-42immunization also appeared to arrest the progression of amyloidosis in older PDAPP mice. A? immunization appears to increase clearance of amyloid plaques, and may therefore be a novel and effective approach for the treatment of AD. |
| Databáze: |
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