| Autor: |
Okubo, Takehito, Harada, Shoji, Higuchi, Susumu, Matsushita, Sachio |
| Zdroj: |
Alcoholism: Clinical and Experimental Research; August 2003, Vol. 27 Issue: Supplement 1 p68S-71S, 4p |
| Abstrakt: |
Background: NRH‐quinone oxidoreductase 2 (NQO2) along with glutathione S‐transferase M1 (GSTM1) and NAD(P)H‐quinone oxidoreductase 1 (NQO1), which is involved in phase II detoxification reactions, is thought to be important for detoxification of catechol o‐quinones in the central nervous system. Our previous study revealed that the human NQO2 gene is highly polymorphic. In this study, we investigated a possible association between polymorphisms of the GSTM1, NQO1, and NQO2 genes and alcohol withdrawal symptoms such as delirium tremens, hallucination, and seizure. |
| Databáze: |
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