FriedelCrafts heteroarylation of heteroarenes: A facile entry to 4heteroaryl quinazolines and quinolines

Autor: Kumar, Shailesh, Sahu, Devi Prasad
Zdroj: Journal of Heterocyclic Chemistry; July 2009, Vol. 46 Issue: 4 p748-755, 8p
Abstrakt: Anhydrous AlCl3mediated heteroarylation of various arenes and heteroarenes with 2,4dichloroquinazoline 1 and 4chloroquinoline 4 afforded exclusively 4arylheteroarylquinazolines 3 and 4arylheteroarylquinolines 5, respectively. Compared with the available synthetic protocols, aluminum chloride induced CC bond formation is direct and convenient to access bisheteroaryl quinazolines and quinolines. The products were obtained in good to excellent yields by this method. J. Heterocyclic Chem., 2009.
Databáze: Supplemental Index