| Autor: |
Sabbatani, Sergio, Manfredi, Roberto, Fulgaro, Ciro, Bon, Isabella |
| Zdroj: |
Current HIV Research; May 2009, Vol. 7 Issue: 3 p311-313, 3p |
| Abstrakt: |
A reversal of key HIV protease mutations against tipranavir has been observed in a patient undergoing a late salvage antiretroviral therapy. Our patient initially introduced tipranavir/ritonavir in absence of an optimized background and novel drug classes, and nevertheless he experienced a virological-immunological benefit. Our report is a contribution to the present debate around the role of each single HIV protease mutation, and the validation of mutational “scores” (like the so-called tipranavir weighted score), to be applied to last-generation protease inhibitor compounds initially targeted on patients with limited, residual therapeutic options. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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