| Autor: |
Tilquin, Pierre, Barrow, Paul A., Marly, José, Pitel, Frédérique, Plisson-Petit, Florence, Velge, Philippe, Vignal, Alain, Baret, Philippe V., Bumstead, Nat, Beaumont, Catherine |
| Zdroj: |
Genetics Selection Evolution; November 2005, Vol. 37 Issue: 6 |
| Abstrakt: |
Selection for increased resistance to Salmonellacolonisation and excretion could reduce the risk of foodborne Salmonellainfection. In order to identify potential loci affecting resistance, differences in resistance were identified between the N and 61inbred lines and two QTL research performed. In an F2 cross, the animals were inoculated at one week of age with Salmonella enteritidisand cloacal swabs were carried out 4 and 5 wk post inoculation (thereafter called CSW4F2 and CSW4F2) and caecal contamination (CAECF2) was assessed 1 week later. The animals from the (N × 61) × N backcross were inoculated at six weeks of age with Salmonella typhimuriumand cloacal swabs were studied from wk 1 to 4 (thereafter called CSW1BC to CSW4BC). A total of 33 F2and 46 backcross progeny were selectively genotyped for 103 and 135 microsatellite markers respectively. The analysis used least-squares-based and non-parametric interval mapping. Two genome-wise significant QTL were observed on Chromosome 1 for CSW2BC and on Chromosome 2 for CSW4F2, and four suggestive QTL for CSW5F2 on Chromosome 2, for CSW5F2 and CSW2BC on chromosome 5 and for CAECF2 on chromosome 16. These results suggest new regions of interest and the putative role of SAL1. |
| Databáze: |
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