| Autor: |
Werner, David F., Swihart, Andrew R., Ferguson, Carolyn, Lariviere, William R., Harrison, Neil L., Homanics, Gregg E. |
| Zdroj: |
Alcoholism: Clinical and Experimental Research; February 2009, Vol. 33 Issue: 2 p289-299, 11p |
| Abstrakt: |
Background: Although many people consume alcohol (ethanol), it remains unknown why some become addicted. Elucidating the molecular mechanisms of tolerance and physical dependence (withdrawal) may provide insight into alcohol addiction. While the exact molecular mechanisms of ethanol action are unclear, γ‐aminobutyric acid type A receptors (GABAA‐Rs) have been extensively implicated in ethanol action. The α1 GABAA‐R subunit is associated with tolerance and physical dependence, but its exact role remains unknown. In this report, we tested the hypothesis that α1‐GABAA‐Rs mediate in part these effects of ethanol. |
| Databáze: |
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