| Autor: |
Dorsky, R I, Raible, D W, Moon, R T |
| Zdroj: |
Genes & Development; January 2000, Vol. 14 Issue: 2 p158-162, 5p |
| Abstrakt: |
We have shown that Wnt signals are necessary and sufficient for neural crest cells to adopt pigment cell fates. nacre, a zebrafish homolog of MITF, is required for pigment cell differentiation. We isolated a promoter region of nacre that contains Tcf/Lef binding sites, which can mediate Wnt responsiveness. This promoter binds to zebrafish Lef1 protein in vitro, and a nacre reporter construct is strongly repressed by dominant-negative Tcf in melanoma cells. Mutation of Tcf/Lef sites abolishes Lef1 binding and reporter function in vivo. Wnt signaling therefore directly activates nacre, which in turn leads to pigment cell differentiation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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