| Autor: |
Dai, Z, Quackenbush, R C, Courtney, K D, Grove, M, Cortez, D, Reuther, G W, Pendergast, A M |
| Zdroj: |
Genes & Development; May 1998, Vol. 12 Issue: 10 p1415-1424, 10p |
| Abstrakt: |
Oncogenic forms of the Abl and Src tyrosine kinases trigger the destruction of the Abi proteins, a family of Abl-interacting proteins that antagonize the oncogenic potential of Abl after overexpression in fibroblasts. The destruction of the Abi proteins requires tyrosine kinase activity and is dependent on the ubiquitin-proteasome pathway. We show that degradation of the Abi proteins occurs through a Ras-independent pathway. Significantly, expression of the Abi proteins is lost in cell lines and bone marrow cells isolated from patients with aggressive Bcr-Abl-positive leukemias. These findings suggest that loss of Abi proteins may be a component in the progression of Bcr-Abl-positive leukemias and identify a novel pathway linking activated nonreceptor protein tyrosine kinases to the destruction of specific target proteins through the ubiquitin-proteasome pathway. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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