| Autor: |
Vanderwal, C. D., Vosburg, D. A., Sorensen, E. J. |
| Zdroj: |
Organic Letters; December 2001, Vol. 3 Issue: 26 p4307-4310, 4p |
| Abstrakt: |
During our efforts to synthesize the cytotoxic natural product FR182877, we discovered intramolecular reductive acylations that offer a stereocontrolled alternative to the classical Knoevenagel condensation for the formation of α-alkylidene β-keto-δ-lactones. Other progress toward a synthesis of FR182877 includes a π-allyl Stille coupling and a bromo Horner−Wadsworth−Emmons reaction that forms a 12-membered ring. Structural relationships among FR182877, hexacyclinic acid, macquarimicin A, and cochleamycin A are also discussed. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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