| Autor: |
Kuroda, R, Neidle, S, Riordan, J M, Sakai, T T |
| Zdroj: |
Nucleic Acids Research; August 1982, Vol. 10 Issue: 15 p4753-4763, 11p |
| Abstrakt: |
The crystal and molecular structure of the title compound, an analogue of the DNA binding region of bleomycin A2, has been determined by X-ray crystallography. All the three independent molecules in an asymmetric unit are approximately planar with fully extended side chains. A computer graphics model-building study has shown that the phenyl group and the second thiazole ring can be intercalated between the base pairs of the double-stranded deoxydinucleoside phosphate d(CpG), and also that the sulphonium cation can interact with a backbone phosphate group. This model is in accord with NMR spectral data. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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