Combined cisplatin, doxorubicin, and mitomycin for the treatment of advanced pleural mesothelioma Presented at the 32nd Annual Meeting of the American Society of Clinical Oncology, Philadelphia Pennsylvania, May 18-21, 1996.

Autor: Pennucci, Maria Cristina, Ardizzoni, Andrea, Pronzato, Paolo, Fioretti, Marina, Lanfranco, Claudio, Verna, Anna, Giorgi, Guglielmina, Vigani, Antonella, Frola, Carlo, Rosso, Riccardo
Zdroj: Cancer; 15 May 1997, Vol. 79 Issue: 10 p1897-1902, 6p
Abstrakt: In a previous FONICAP trial, the combination of doxorubicin (D) and cisplatin (P) yielded an objective response rate of 25% and a subjective response rate of 50% in patients with mesothelioma. In human mesothelioma cell lines, mitomycin (M) showed a synergic activity with P and in a recent randomized study, the combination of M and P showed slightly superior activity when compared with the PD regimen. The authors tested the activity and toxicity of a combination chemotherapy regimen including P, 60 mg/m2, D, 60 mg/m2, and M, 10 mg/m2, all by intravenous infusion on Day 1 every 28 days in a Phase II study. Twenty-four chemotherapy-naive mesothelioma patients were enrolled in the study. Patient characteristics were the following: the median age was 58 years; the median performance status was 1; there were 6 Stage I patients, 15 Stage II patients, 2 Stage III patients, and 1 Stage IV patient; and 10 patients had previous asbestos exposure. All patients had pretreatment symptoms: 13 had chest pain, 9 had pleural effusion, and 7 had dyspnea. A total of 78 cycles of chemotherapy were administered. The only significant side effect was myelosuppression, with only 9.5% of patients having Grade 4 toxicity. Among 23 patients evaluable for response, 5 achieved a partial response (20.8%; 95% confidence interval, 7.1-42.1%), 9 had stable disease, and 9 had progressive disease (including 1 early death). One patient was not evaluable because of treatment refusal. A clinical improvement was observed in 7 of 24 patients (29%). The combination of PDM in patients with pleural mesothelioma is feasible and moderately active. However, the observed level of activity is similar to that obtained with other two-drug regimens. Cancer 1997; 79:1897-902. © 1997 American Cancer Society.
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