| Autor: |
Ueda, Mitsuru, Yamaura, Masashi, Ikeda, Yoichi, Suzuki, Yuta, Yoshizato, Kensaku, Hayakawa, Ichiro, Kigoshi, Hideo |
| Zdroj: |
The Journal of Organic Chemistry; 20240101, Issue: Preprints p3370-3377, 8p |
| Abstrakt: |
The total synthesis of haterumalides NA and B, potent cytotoxic marine macrolides, was achieved by using B-alkyl Suzuki−Miyaura coupling and Nozaki−Hiyama−Kishi coupling as key steps. Compared to our first-generation approach for ent-haterumalide NA methyl ester, this second-generation synthesis yielded much more of the key intermediate. This synthesis established the relative stereochemistry of haterumalide B. Furthermore, the structure−cytotoxicity relationships of haterumalides were investigated. The combination of macrolide and side chain parts proved to be important to the cytotoxicity. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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