| Autor: |
Das, U.N., Krishna Mohan, I., Ravi Raju, T. |
| Zdroj: |
Prostaglandins, Leukotrienes and Essential Fatty Acids; October 2001, Vol. 65 Issue: 4 p197-203, 7p |
| Abstrakt: |
It is known that the concentrations of essential fatty acids and their metabolites including eicosanoids, free radicals and anti-oxidants are altered in glomerular disorders. Both corticosteroids and n-3 fatty acids–eicosapentaenoic acid and docosahexaenoic acid (EPA and DHA respectively) – are useful in the management of glomerular disorders. In the present study, the altered plasma concentrations of lipid peroxides, nitric oxide and the metabolites of essential fatty acids and anti-oxidants – superoxide diamutase, glutathione peroxidase and vitamin E – in the RBC membranes of patients with glomerular disorders (nephrotic syndrome) reverted to normalcy following corticosteroids or EPA/DHA administration. This suggests that the beneficial actions of corticosteroids and EPA/DHA in glomerular disorders can be attributed to their action on the pro-oxidant and anti-oxidant concentrations and metabolism of essential fatty acids. |
| Databáze: |
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