| Autor: |
Lollini, Pier-Luigi, Nicoletti, Giordano, Landuzzi, Lorena, Giovanni, Carla De, Rossi, Ilaria, Carlo, Emma Di, Musiani, Piero, Muller, William J., Nanni, Patrizia |
| Zdroj: |
International Journal of Cancer; 11 September 1998, Vol. 77 Issue: 6 p937-941, 5p |
| Abstrakt: |
Transgenic mice carrying the HER-2/neu proto-oncogene under tissue-specific transcriptional control of a mammary tumor virus long terminal repeat (Tg-MMTVneu mice) spontaneously develop mammary carcinomas. HER-2/neu is a tumor antigen that can be recognized by cytotoxic T lymphocytes if tumor cells present the appropriate major histocompatibility complex (MHC) class I glycoproteins. The purpose of this work was to assess whether mammary carcinomas arising in Tg-MMTVneu mice correctly expressed MHC (H-2q) class I gene products. We analyzed by flow cytometry 51 primary tumors from 19 transgenic mice. About one-half of the tumors showed a reduced expression of class I antigens. All tumors were highly positive for membrane neu. Some mice had multiple mammary carcinomas with widely different MHC expression levels, and most mice had at least one tumor with a low expression. Treatment with γ-interferon of carcinoma cells cultured in vitro induced a strong re-expression of H-2q antigens. Our results suggest that the immune response activated in vivo by HER-2/neu-positive tumors can lead to the emergence of escape variants characterized by a down-regulation of MHC class I products. Int. J. Cancer 77:937941, 1998.© 1998 Wiley-Liss, Inc. |
| Databáze: |
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