| Autor: |
Laak, M.P. ter, Lankhorst, A.J., Schrama, L.H., Gispen, W.H. |
| Zdroj: |
Neuroscience Research Communications; May/June 2000, Vol. 26 Issue: 3 p227-239, 13p |
| Abstrakt: |
The peripheral nervous system is very vulnerable to damage of various origin. This results in neuropathies, which can be multifactorial. In this chapter we will focus our attention to 3 human neuropathies for which we have successfully developed and used animal models, i.e., diabetes mellitus-induced neuropathy, the immune-mediated Guillain-Barré syndrome (and its animal equivalent experimental allergic neuritis) and a toxic neuropathy caused by the cytostatic drug cisplatin. For these neuropathies we will describe the human etiology and pathology, followed by a description of the corresponding animal model which we have developed for laboratory rats. Furthermore, the parameters by which the diseases is monitored in the animal models are discussed. Finally, the human neuropathy and its animal model are compared. |
| Databáze: |
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