| Autor: |
Rood, M. J., Krugten, M. V. Van, Zanelli, E., Linden, M. W. Van Der, Keijsers, V., Schreuder, G. M. T., Verduyn, W., Westendorp, R. G. J., Vries, R. R. P. De, Breedveld, F. C., Verweij, C. L., Huizinga, T. W. J. |
| Zdroj: |
Arthritis & Rheumatism; January 2000, Vol. 43 Issue: 1 p129-134, 6p |
| Abstrakt: |
To evaluate the respective contributions of tumor necrosis factor (TNF) promoter polymorphisms and HLADR alleles to susceptibility to systemic lupus erythematosus (SLE). TNF-238G/A and 308G/A promoter polymorphisms and HLADRB1 alleles were determined in 99 consecutive Caucasian SLE patients and 177 Caucasian controls. Standard and Mantel-Haenszel odds ratios were calculated to assess the magnitude of the susceptibility factors. The presence or absence of the SLE classification criteria was determined and correlated with the TNF promoter and HLADRB1 genotypes. The frequency of the TNF-308A/A and 308G/A genotypes was significantly higher in SLE patients (odds ratio 5.0). Conversely, TNF-238G/A and 238A/A genotypes were equally prevalent in SLE patients and controls. The HLADR3 specificity (DRB1*0301 allele) was significantly more prevalent in the SLE population (odds ratio 4.4). Stratification to correct for interdependence of the 2 loci confirmed the association of both TNF-308A and HLADR3 with SLE (Mantel-Haenszel odds ratio 3.2 and 2.4, respectively). No correlation was found between TNF promoter and HLADRB1 genotypes and any SLE classification criterion or disease manifestation. TNF-308A and HLADR3 alleles are independent susceptibility factors for SLE. |
| Databáze: |
Supplemental Index |
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