| Autor: |
Rapaport, Hanna, Kuzmenko, Ivan, Lafont, Sylvaine, Kjaer, Kristian, Howes, Paul B., Als-Nielsen, Jens, Lahav, Meir, Leiserowitz, Leslie |
| Zdroj: |
Biophysical Journal; November 2001, Vol. 81 Issue: 5 p2729-2736, 8p |
| Abstrakt: |
The growth of a cholesterol crystalline phase, three molecular layers thick at the air-water interface, was monitored by grazing incidence x-ray diffraction and x-ray reflectivity. Upon compression, a cholesterol film transforms from a monolayer of trigonal symmetry and low crystallinity to a trilayer, composed of a highly crystalline bilayer in a rectangular lattice and a disordered top cholesterol layer. This system undergoes a phase transition into a crystalline trilayer incorporating ordered water between the hydroxyl groups of the top and middle sterol layers in an arrangement akin to the triclinic 3-D crystal structure of cholesterol · H2O. By comparison, the cholesterol derivative stigmasterol transforms, upon compression, directly into a crystalline trilayer in the rectangular lattice. These results may contribute to an understanding of the onset of cholesterol crystallization in pathological lipid deposits. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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