Mycophenolic Derivatives from Eupenicilliumparvum

Autor: Habib, Eman, León, Francisco, Bauer, John D., Hill, Robert A., Carvalho, Paulo, Cutler, Horace G., Cutler, Stephen J.
Zdroj: Journal of Natural Products; December 2008, Vol. 71 Issue: 11 p1915-1918, 4p
Abstrakt: A new compound, euparvic acid (1, C14H16O6), and the known compounds 5,7-dihydroxy-4-methylphthalide (2), 6-(3-carboxybutyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (3), 6-(5-carboxy-3-methylpent-2-enyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (4), and 6-(5-carboxy-4-hydroxy-3-methylpent-2-enyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (5) were isolated from the EtOAc extract of Eupenicillium parvum. The structure of 1was determined by interpretation of MS and homo- and heteronuclear 2D NMR spectroscopic data and confirmed by X-ray crystallography. The absolute configuration of 5was determined via MPA ester derivatization.
Databáze: Supplemental Index