| Autor: |
Grebow, Peter E., Johnston, Martha M., Mellett, L B |
| Zdroj: |
Current Medical Research and Opinion; 1977, Vol. 5 Issue: 1, Supplement 1 p9-12, 4p |
| Abstrakt: |
SummaryA fluorescence assay for indapamide which is both sensitive and capable of handling large numbers of samples has been developed. Reaction of indapamide with NaOH at 100°C has been shown to yield a fluorescent product, which has excitation and emission wavelengths of 284 nm and 356 nm, respectively. The assay is sensitive to levels of indapamide of 0.025 μg/ml in aqueous solutions, and a linear calibration curve between 0.025 μg/ml and 2 μg/ml is observed. The adaptability of this assay to urinary samples of the drug has been demonstrated by the development of a selective extraction procedure. Using this procedure, there was no interference in the assay from endogenous urinary compounds. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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