| Autor: |
Verho, M., Malercxyk, V., Rosenkranz, B., Grotsch, H. |
| Zdroj: |
Current Medical Research and Opinion; 1987, Vol. 10 Issue: 7 p474-479, 6p |
| Abstrakt: |
SummaryThe effect of of loxacin on steady-state phenprocoumon pharmacodynamics was investigated in 7 healthy male volunteers taking daily sub-therapeutic doses of phenprocoumon. Ofloxacin 200 mg once daily for 7 days did not alter the anticoagulant response (Quick values) to phenprocoumon after a stabilization phase of 2 weeks. Mean Quick values during the steady-state phase before and during ofloxacin administration were. 54% and 52%, respectively. In vitro studies with concentrations of 0 to 100 mg ofloxacin/l added to plasma also failed to show any interaction. The results indicate, therefore, that ofloxacin does not interfere with vitamin K-dependent coagulation cascade, as seen after other antibiotics. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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