| Autor: |
Bacon, P., Luqmani, R. A., Bossingham, D. H., Daymond, T. J., Grahame, R., West, J., Hademan, B. L., Adebajo, A. O., Hughes, G. R. V., Abdullah, M., Huskisson, E. C., Raman, D., White, A. G., Williams, B. D., Williams, P., Woolf, A. D., Miller, A. J. |
| Zdroj: |
Current Medical Research and Opinion; 1990, Vol. 12 Issue: 2 p128-134, 7p |
| Abstrakt: |
SummaryThe efficacy and side-effect profiles of two formulations of indomethacin were compared in a multi-centre, double-blind, crossover study in 77 patients with osteoarthritis. Patients were allocated at random to receive 75 mg indomethacin per day either as 1 controlled-release tablet at night or as 1 immediate-release capsule given 3-times daily for a period of 4 weeks, after which patients were crossed over to receive the alternative treatment, for a further 4 weeks. Pain scores, daily symptomatology and the requirement for escape analgesia recorded by the investigator and patient indicate that controlled-release indomethacin tablets, 75 mg given at night, were as efficacious as immediate-release indo-methacin capsules, 25 mg given 3-times daily, in the treatment of osteoarthritis. The side-effect profiles of the two formulations were similar. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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