| Autor: |
Ruud, T. E., Hoff, G., Tønder, M., Holter, O. |
| Zdroj: |
Current Medical Research and Opinion; 1980, Vol. 6 Issue: 1, Supplement 9 p37-40, 4p |
| Abstrakt: |
SummaryDoxepin reduces both basal and pentagastrin-stimulated output of gastric acid and pepsin in man. An open study was carried out, therefore, in 43 patients with endo-scopically confirmed duodenal ulcers to compare the effectiveness of doxepin (50 mg at night) or cimetidine (200200200400 mg daily) for 6 weeks. Endoscopic examinations at 3 and 6 weeks were performed blindly. At 3 weeks, 60 of the patients treated with doxepin and 59 of those receiving cimetidine revealed endo-scopically healed ulcers. At 6 weeks, 84 of the patients treated with doxepin and 82 of those receiving cimetidine were found to have endoscopically healed ulcers. No statistically significant differences in pain relief and assessments of patient well-being were found. Ulcer relapse occurred in 4 patients in the doxepin group and in 6 in the cimetidine group within 3 months. Thus, no significant differences in either healing frequency or pain relief were found in the two groups studied. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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