| Autor: |
Lascano, E. F., Lerman, G. D., Blejer, J. L., Caccuri, R. L., Berría, M. I. |
| Zdroj: |
Archives of Virology; March 1992, Vol. 122 Issue: 1-2 p13-22, 10p |
| Abstrakt: |
To determine the pathway adopted by peripherally inoculated Junin virus (JV) to reach the CNS, rat tissues were serially harvested to trace the sequence of viral progression from right hind footpad to brain. Immunoperoxidase (PAP) labeling of viral antigen, concomitantly with infectivity assays and histological examination of each selected sample, were carried out. As from the 2nd week post-infection (pi), neurological disease inducing 100% mortality at 1 month was evident. At day 5 pi, viral antigen was first detected at footpad level in epidermic and dermic cells, as well as in neighbouring myocytes; labeled macrophages infiltrating small nerve branches were also disclosed. As from 10–15 days pi, viral antigen became apparent along ipsilateral sciatic nerve structures and within lumbar spinal ganglion neurons, followed by a fast viral spread throughout CNS neurons that involved spinal cord and brain. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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