Epithelial permeability in corneal grafts by fluorophotometry

Autor: Boot, Johan P., Best, Jaap A., Stolwijk, Thorsten R., Sterk, Caesar C.
Zdroj: Graefe's Archive for Clinical and Experimental Ophthalmology; November 1991, Vol. 229 Issue: 6 p533-535, 3p
Abstrakt: The epithelial permeability to fluorescein of 27 clear corneal grafts in 23 patients was determined by fluorophotometry at > 1 year after penetrating keratoplasty (PKP) so as to study the recovery of corneal epithelial function. The mean epithelial permeability of the corneal grafts did not differ significantly from that of normal corneas (0.042 ± 0.016 and 0.038 ± 0.017 nm/s, respectively; P>0.3). Multiple linear regression analysis showed that permeability correlated with recipient age but not with donor age (permeability increase, 0.00054 nm/s per year; r=0.6, P<0.005 and r=0.1, P>0.5, respectively). These results indicate that corneal grafts can regain a normal epithelial barrier function and that recovery of epithelial function is better in young than in old recipients.
Databáze: Supplemental Index