| Abstrakt: |
Abstract: The present study was designed to determine the effectiveness of medium chain triglycerides (MCT) as inhibitors of gastric secretion in rats after the diversion of bile into the descending colon. One-half of the experimental animals had biliary flow diverted to the descending colon, while the other one-half received sham operations. Twenty-four hours later, either 1 ml of saline, olive oil, or medium chain triglycerides was injected directly into the upper duodenum at the time of pyloric ligation. The administration of olive oil resulted in a significant inhibition of gastric volume, acid and pepsin secretion in the sham-operated animals, but not in animals with biliary diversion. The administration of medium chain triglycerides resulted in a significant inhibition of gastric volume and acid output in both, the sham operated and biliary-diverted rats. Since bile diversion does not affect the rate of absorption of MCT but does reduce the rate of absorption of olive oil, these results support the concept of a relationship between digestion and/or absorption of fat with the inhibition of gastric secretion. |
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