Blood exchange and transfusion therapy for acute cholestasis in protoporphyria

Autor: Van Wijk, Hans J., Van Hattum, Jan, De La Faille, Harold Baart, Van Den Berg, J. Willem O., Edixhoven-Bosdijk, Annie, Wilson, J. H. Paul
Zdroj: Digestive Diseases and Sciences; December 1988, Vol. 33 Issue: 12 p1621-1625, 5p
Abstrakt: Summary Acute cholestasis is a rare complication of EPP with a high mortality rate despite extensive treatment with corticosteroids, cholestyramine, and antioxidants. A single survivor, reported in the literature, was treated with blood exchange transfusions. We treated two EPP patients with blood exchange and additional blood transfusions which resulted in full clinical and biochemical recovery from the cholestasis and accompanying hepatitis. Recurrences of the cholestasis and hepatitis could repeatedly be corrected by additional blood transfusions.
Databáze: Supplemental Index