| Autor: |
Tucci, Antonio, Corinaldesi, Roberto, Stanghellini, Vincenzo, Paparo, Giovanni F., Gasperoni, Stefano, Biasco, Guido, Varoli, Ornella, Ricci-Maccarini, Marco, Barbara, Luigi |
| Zdroj: |
Digestive Diseases and Sciences; September 1993, Vol. 38 Issue: 9 p1670-1673, 4p |
| Abstrakt: |
The present study evaluated the effect of a one-day high-dose combined therapy onHelicobacter pylori infection. Thirty-two consecutive patients (suffering from either peptic ulcer or nonulcer dyspepsia) withHelicobacter pylori infection received omeprazole (40 mg) +bismuth subcitrate (240 mg×4)+amoxicillin suspension (2000 mg×4)+metronidazole (500 mg×4), for only one day. Endoscopy, histology, culture, and susceptibility studies were done at entry and 30 and 90 days after the treatment day. Successful eradication was obtained in 23/32 (72%) patients and gastritis had resolved in 95% of these. Side effects were induced by the treatment in 6/32 (19%) patients, but these were all self-limiting, short-lasting, and did not require any specific treatment. Development of bacterial resistance to metronidazole occurred in 6/9 (67%) non-eradicated patients. These data suggest that one-day treatment with high doses of amoxicillin, metronidazole, bismuth, and omeprazole represents an effective, safe, and inexpensive therapeutic approach for the treatment ofH. pylori infection. |
| Databáze: |
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