| Autor: |
Michel, Pierre, Joly, Pascal, Ducrotte, Philippe, Hemet, Jacques, Leblanc, Isabelle, Lauret, Philippe, Lerebours, Eric, Colin, Raymond |
| Zdroj: |
Digestive Diseases and Sciences; October 1993, Vol. 38 Issue: 10 p1938-1941, 4p |
| Abstrakt: |
Summary Intestinal involvement in toxic epidermal necrolysis (TEN) has been identified only rarely. This report describes a case of TEN with ileal manifestations characterized by a profuse diarrhea with malabsorption, protein-losing enteropathy, and radiologically by multiple stenosis. After healing of the cutaneous lesions, total parenteral nutrition was initiated, resulting in a decreased diarrhea. However, after one month of total parenteral nutrition, malabsorption and protein-losing enteropathy continued and the radiological lesions were still present with an aspect consistent with a sclerotic process. A surgical resection of the pathological ileal segment was performed with end-to-end anastomosis. Pathological examination of the resected segment showed a necrosis of the ileal mucosa with a pattern similar to that of the epidermal necrosis. No sclerosis was observed. It seems that a prolonged total parenteral nutrition could have induced a complete healing of intestinal lesions. This case report is the first clinical, radiological, and histological study of an ileal involvement in TEN. |
| Databáze: |
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