| Autor: |
Werbovetz, Karl A., George, Tesmol G., Richard, Julian, Barszcz, Todd, Capers, Jeffrey |
| Zdroj: |
Letters in Drug Design & Discovery; January 2008, Vol. 5 Issue: 1 p69-73, 5p |
| Abstrakt: |
Several flavylium salts showed potent (albeit nonselective) activity against L. donovani axenic amastigotes and T. b. brucei bloodstream forms in vitro (IC50 values ranging from 0.75 to 35 μM). The trans-chalcone, which forms from the corresponding flavylium salt at neutral pH in aqueous solution, is proposed to be the active species. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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