Synthesis and reduction of esters of N-(4-amino-5-nitro-6-pyrimidyl)amino acids

Autor: Cherkasov, V. M., Kapran, N. A., Tret'yakova, G. S., Latenko, V. A.
Zdroj: Chemistry of Heterocyclic Compounds; January 1969, Vol. 5 Issue: 1 p98-100, 3p
Abstrakt: The reaction of esters of amino acids with 4-amino-6-chloro-5-nitropyrimidine has yielded esters of (4-amino-5-nitro-6-pyrimidyl)amino acids. The reduction of the esters of a-(4-amino-5-nitro-6-pyrimidylamino) acids has yielded 4-amino-6-hydroxy-7,8-dihydropteridines. a-(4-Amino-5-nitro-6-pyrimidylamino) acids and the ester of N-(4-amino-5-nitro-6-pyrimidyl)-ß-alanine do not cyclize and on reduction give the corresponding diaminopyrimidine derivatives.
Databáze: Supplemental Index