Effect of meso substituents on the NH acidities of benzimidazoles

Autor: Kashik, T. V., Ponomareva, S. M., Abramova, N. D., Skvortsova, G. G.
Zdroj: Chemistry of Heterocyclic Compounds; September 1983, Vol. 19 Issue: 9 p997-1000, 4p
Abstrakt: The NH acidities of a systematic series of 2-substituted benzimidazoles in acetonitrile were studied by potentiometric titration. It was found that the intramolecular interrelationships between the substituent in the 2 position and the acidity center have primarily inductive character and are expressed quantitatively by a dependence of the pKa = f(sm) type.
Databáze: Supplemental Index