Reaction of 2-cyanomethylbenzimidazole with alkyl halides

Autor: Anisimova, V. A., Askalepova, O. I., Bagdasarov, K. N., Chernov'yants, M. S.
Zdroj: Chemistry of Heterocyclic Compounds; March 1988, Vol. 24 Issue: 3 p281-284, 4p
Abstrakt: Refluxing 2-cyanomethylbenzimidazole in alcohol with alkyl halides led to low yields of N-alkylated products. Addition of base to the reaction mixture shifted the course of the reaction to form mainly N,C-dialkyl substituted products. In DMF or with an excess of alkyl halide at elevated temperature both N-mono- and N,N-dialkyl substituted materials were formed together.
Databáze: Supplemental Index