| Autor: |
Grishina, G. V., Gaidarova, E. L., Luk'yanenko, E. R., Borisenko, A. A. |
| Zdroj: |
Chemistry of Heterocyclic Compounds; February 1996, Vol. 32 Issue: 2 p194-196, 3p |
| Abstrakt: |
The stereochemistry of the asymmetric reduction of the imine obtained from 1,3-dimethylpiperidin-4-one and (S)-a-phenylethylamine has been studied. It is shown that hydride reduction of imine 1 by sodium borohydride in methanol is asymmetric and gives the cis and trans diastereomeric pair 1,3-dimethyl-4-(a-phenyl-ethylamino) piperidine in the ratio 3:1. Using sodium in isopropanol gives only one trans diastereomeric pair.1H NMR has been used to identify the stereochemical structure and diastereomer excess of the cis and trans isomers of 1,3-dimethyl-4-(a-phenylethylamino)piperidine which had been separated by column chromatography. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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