| Autor: |
Vinogradov, M. G., Kalgorodova, L. N., Chel'tsova-Bebutova, G. V., Gorshkova, L. S., Starostin, E. K., Nikishin, G. I., Ignatenko, A. V., Shapiro, E. A. |
| Zdroj: |
Russian Chemical Bulletin; January 1995, Vol. 44 Issue: 1 p167-171, 5p |
| Abstrakt: |
A convenient preparative synthesis of cilastatin, an inhibitor of renal dipeptidase used in drugs with the antibiotic imipenem, has been elaborated. The key intermediate in this synthesis is 2-amino-7-chloroheptanoic acid prepared by oxidative cleavage of cycloheptanone followed by bromination of 7-chloroheptanoyl chloride with subsequent amination of the 2-bromo-7-chloroheptanoic acid thus formed. All of the stages of the new synthesis are easily performed, as is the isolation of the intermediate products, and they do not require any organometallic reagents. |
| Databáze: |
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| Externí odkaz: |
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