Autor: |
Godunova, L. F., Karpeiskaya, E. I., Levitina, E. S., Klabunovskii, E. I., Yagupol'skii, Yu. L., Kolycheva, M. T. |
Zdroj: |
Russian Chemical Bulletin; June 1987, Vol. 36 Issue: 6 p1254-1256, 3p |
Abstrakt: |
1.In reductive aminolysis of p-fluoroacetaminocinnamic acid azalactone by S-(-)-a-phenylethylamine in the presence of PdCl2 and H2 in dimethoxyethane or isopropyl alcohol, N-acetyl-p-fluorophenylalanine phenylethylamide was formed with 28 and 46% excesses of the SS diastereomer, respectively, the hydrolysis of which, after crystallization, afforded optically pure S-(-)-p-fluorophenylalanine.2.Hydrogenation of p-fluoroacetaminocinnamic acid S-(+)-phenylethylamide in isopropyl alcohol and dimethoxyethane occurred stereoselectively and afforded N-acetyl-p-fluorophenyl-alanine phenylethylamide with 10% excess of the RS diastereomer. |
Databáze: |
Supplemental Index |
Externí odkaz: |
|