Synthesis and anticholinesterase activity of S-ethynyl dialkylthiophosphates with cyclic substituents at the acetylenic bond

Autor: Godovikov, N. N., Vikhreva, L. A., Darisheva, A. M., Balashova, I. K., Moralev, S. N., Brestkin, A. P., Rozengart, V. I., Sherstobitov, O. E., Kabachnik, M. I.
Zdroj: Russian Chemical Bulletin; January 1987, Vol. 36 Issue: 1 p152-157, 6p
Abstrakt: 1.Some S-ethynyl dialkylthiophosphates with cyclic radicals at the acetylenic bond have been prepared.2.S-Ethynyl thiophosphates with a cyclohexyl substituent at the acetylenic bond possess the greatest rate constants for the inhibition of cholinesterase from different sources, and the highest values of the acetylene effect in comparison with those of the phenyl and cyclohexenyl derivatives.
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