| Abstrakt: |
1.The 17a,20?-dihydroxy analog of shyogralactone, a natural steroidald-lactone, was synthesized,2.Soutes were studied for inserting 5a hydroxy-6-keto and 5aH-6-keto groupings into ?17(20)-lactones via the 5a,6a epoxide and 5a-hydroxy-6-ketone, and it was shown that the desired products are formed in low yields, in which connection hydrogenation of the ?17(20) bond is difficult. The most acceptable path proved to be insertion of the 3ß-hydroxy-5aH-6-keto grouping via the Sa,5a-cyclosteroid. |
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