New method for dehydrogenation of 1,4-dihydropyridines to pyridines using homogeneous complex palladium catalysts

Autor: Dzhemilev, U. M., Yakupova, A. Z., Minsker, S. K., Tolstikov, G. A.
Zdroj: Russian Chemical Bulletin; March 1978, Vol. 27 Issue: 3 p585-587, 3p
Abstrakt: 1.We were the first to study the dehydrogenation of 1,4-dihydropyridines using catalytic amounts of homogeneous Pd catalysts and it was shown that 2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine and its 4-substituted alkyl-(CH3-C4H9) and aryl- (C6H5, o-C6H4OH, CH=CH-C6H5, p-C6H4-OCH3) derivatives are easily converted to the corresponding pyridines under the influence (10 h, 100°) of the catalyst: Pd(acac)2-P(C4H9)3-Al(C2H5)3-CF3CO2H (1:3:3:10).2)When substituted 1,4-dihydropyridines are dehydrogenated in the presence of 1,5-cyclooctadienes the latter undergo simultaneous selective hydrogenation to the corresponding cyclooctenes.
Databáze: Supplemental Index
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