| Autor: |
Li, Juan, Ren, Xianhui, Huang, Zhaowei, Jin, Yueying, Wang, Zihui, EC, Chew |
| Zdroj: |
Chinese Journal of Cancer Research; June 1999, Vol. 11 Issue: 2 p125-127, 3p |
| Abstrakt: |
Objective: To compare the composition of nuclear matrix proteins (NMP) between leukemia cells and normal bone marrow cells. Methods: NMP was isolated by high-salt extraction and identified in acute and chronic myelogenous leukemia cells as well as in the blast phase of chronic leukemia. On SDS-PAGE, NMPs with molecular myelogenous ferment from what were seen in normal bone marrow cells were present in both acute and chronic myelogenous leukemia. Conclusion: Marked changes of NMP, not only in contents but also in compositions, exist in leukemic cells compared with normal bone marrow cells. NMP may serve as a target of chemotherapeutic drug against leukemia. |
| Databáze: |
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