| Autor: |
Karlsson, G., Klebs, K., Hafner, T., Schmutz, M., Olpe, H. R. |
| Zdroj: |
Experientia; August 1992, Vol. 48 Issue: 8 p748-751, 4p |
| Abstrakt: |
The aim of this study was to investigate the putative role of GABABreceptors in the development of amygdala kindling in rats. The effects of the GABABblocker CGP 35348 and the GABABagonist baclofen on the progressive development of behavioural seizure symptoms (stages 1–5 classified by Racine) and duration of afterdischarges (AD) were studied. CGP 35348 at a dose of 300 mg/kg i.p, which blocks central GABABreceptors, moderately but consistently accelerated the development of behavioural seizure symptoms. CGP 35348 had no marked effect on the duration of ADs corresponding to the different seizure stages. L-baclofen (6 mg/kg i.p.) had a dual effect on kindling development. It retarded the development of the behavioural symptoms, but increased the duration of AD. In conclusion, the results suggest that synaptically-released GABA activated GABABreceptors and thereby exerted a depressant effect on kindling development. |
| Databáze: |
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