| Autor: |
Bakka, A., Johnsen, A. S., Endresen, L., Rugstad, H. E. |
| Zdroj: |
Experientia; March 1982, Vol. 38 Issue: 3 p381-383, 3p |
| Abstrakt: |
An endogenous cytoplasmic protein, metallothionein (MT) apparently gave rise to radioresistance in 2 different cell lines. A dose reduction factor of 1.9 was achieved in MT-containing cells. MT accounted for a 3–4-fold increase of total sulfhydryl groups in the resistant cell strains, compared to the non-resistant lines from which they were derived. The protein is rich in cysteine (30%), an amino acid known to give radioprotection when administered exogeneously. Glutathione levels and cell-cycle phase distribution showed no marked difference between resistant and corresponding non-resistant cells. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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