Enzymatic synthesis of trisialoganglioside by particulate fractions of rat liver

Autor: Richardson, Carol L., Merritt, W. D., Keenan, T. W., Morré, D. James
Zdroj: Experientia; May 1978, Vol. 34 Issue: 5 p571-572, 2p
Abstrakt: Rat liver contains a particulate (membrane-bound) glycosyl transferase, concentrated in Golgi apparatus fractions, which catalyzes the synthesis of a trisialoganglioside from the ganglioside precursor disialohematoside (GD3). Sialic acid was not incorporated into exogenous GD1afrom CMP-N-acetylneuraminic acid suggesting that GD1ais an endproduct of the monosialoganglioside pathway. Thus, the disialoganglioside pathway may be a primary source of trisialoganglioside and higher ganglioside homologs in adult rat liver.
Databáze: Supplemental Index