Electrocardiographic and behavioral effects ofl -DOPA in the guinea-pig

Autor: Marino, A., Girone, E., Battista, O., de Marino, V.
Zdroj: Experientia; September 1970, Vol. 26 Issue: 9 p983-984, 2p
Abstrakt: The effects ofl -DOPA administered per os on conditioning, spontaneous behavior and the electrocardiogram of the guinea-pig are reported and compared.l -DOPA is able to inhibit the conditioned behavior in doses per os without any effect on spontaneous behavior or motility. Moreoverl -DOPA in doses up to 15 times higher than the average therapeutic daily dose pro kg used in man (TDD), does not alter the ECG of the guinea-pig. We did not observe ECG changes even after a total dose pro kg 60 times higher than TDD, which induced behavioral alterations in the 4 treated animals and one death.
Databáze: Supplemental Index