| Autor: |
Sarkisov, D., Fedorov, V., Glushchenko, E., Alekseev, A., Tumanov, V., Serov, G., Vozdvizhenskii, S., Budkevich, L. |
| Zdroj: |
Bulletin of Experimental Biology and Medicine; June 1995, Vol. 119 Issue: 6 p543-547, 5p |
| Abstrakt: |
Abstract: A novel and unique method for treating skin burns by grafting cultured cells to the wound surface is described. The major graft elements are allogeneic human fibroblasts rather than keratinocytes. Experience with its use in 222 severely burned patients, including those after early surgical necrectomy, showed this method to be an effective means of treating “borderline” third-degree burns. Epitheliazation times were shortened from 312 days to 8.40.9 days. When the method was combined with dermatoautoplasty using a 1:6 perforated netted skin flap, the epithelialization period decreased from 202.3 to 121.3 days. The method proved to be highly effective in the treatment of slowly healing wounds in donor areas. It is concluded that the advantages of the proposed method — high efficacy, the much lower costs (in comparison with other methods) because no expensive nutrient media or growth biostimulators have to be used, and the very short time required to obtain a graft from allogeneic fibroblasts-argue for its wide use in clinical practice. |
| Databáze: |
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