Comparative study of the effects of recombinant tumor necrosis factor and synthetic peptides corresponding to its fragments on phagocytosis mediated by Fc- and MF-receptors

Autor: Konyaev, I., Freidlin, I., Maiorov, V., Zav'yalov, V.
Zdroj: Bulletin of Experimental Biology and Medicine; March 1996, Vol. 121 Issue: 3 p280-283, 4p
Abstrakt: Abstract: The effects of human recombinant tumor necrosis factor and its peptides on the macrophage-like cells of continuous cell line P388D1 were studied. One of the peptides, 123–131, was found capable of not only mimicking, but also of blocking the effects of recombinant tumor necrosis factor. The results permit us to tentatively identify the 123–131 site of the factor molecule as being responsible for its activating effect on macrophages.
Databáze: Supplemental Index
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