| Autor: |
Bogatskii, A. V., Golovenko, N. Ya., Zin'kovskii, V. G. |
| Zdroj: |
Bulletin of Experimental Biology and Medicine; January 1980, Vol. 89 Issue: 1 p32-35, 4p |
| Abstrakt: |
Excretion of phenazepam and its metabolites in the bile and its intrahepatic circulation were studied in two groups of rats: bile donors receiving an intravenous injection of14C-phenazepam (14 mg/kg) previously, and recipients into whose duodenum the donors' bile was introduced. Phenazepam (compound I), its free-hydroxy metabolites (compound II), and a metabolite with a hydroxyl group in the aromatic ring (compound III) were shown to be excreted in the bile of these animals. Hydroxyl derivatives are excreted in the bile in the form of glucuronides also. Compounds I and III and the glucuronide of compound III undergo intrahepatic circulation. |
| Databáze: |
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| Externí odkaz: |
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