Effect of age, castration, and pregnancy on carcinogenesis induced in CBA mice by 1,2-dimethylhydrazine

Autor: Turusov, V. S., Bazlova, L. S., Krutovskikh, V. A.
Zdroj: Bulletin of Experimental Biology and Medicine; May 1979, Vol. 87 Issue: 5 p478-481, 4p
Abstrakt: When injected subcutaneously in a dose of 8 mg/kg weekly into female CBA mice, 1,2-dimethylhydrazine (DMH) induced the development of tumors of the intestine, anal region, uterus, and liver. When DMH was injected into mice aged 12–13 months the appearance of sarcomas of the uterus was observed earlier (at 8 weeks) and the incidence of tumors of the anal region rose more rapidly than in mice aged 3 months. In mice receiving DMH against the background of repeated pregnancies, a statistically significant decrease in the frequency of sarcomas of the uterus was observed (10.3% compared with 48.3% in nonpregnant mice); pregnancy did not affect the frequency of tumors of other organs. Castration had no significant effect on the time of appearance or the frequency of tumors in all situations.
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