| Autor: |
Bakhanashvili, T. A., Blinkova, N. F., Maisov, N. I. |
| Zdroj: |
Bulletin of Experimental Biology and Medicine; March 1979, Vol. 87 Issue: 3 p226-229, 4p |
| Abstrakt: |
Uptake of dopamine-3H by synaptosomes and glial cells of the rabbit cerebral cortex and synaptosomes of the rat cerebral cortex was investigated. The value of Km for dopamine-3H uptake was found to be the same (0.075±0.01 µM) for both synaptosomes and glial cells. Rabbit cortical synaptosomes took up dopamine-3H twice as fast as glial cells (the rate of uptake was compared in terms of protein). Among the psychotropic drugs studied, the most active inhibitors of synaptosomal uptake were amphetamine and cocaine, but they were less active against glial uptake. Neuroleptics and antidepressants inhibited both types of uptake equally. The results are in agreement with the view that the mechanism of action of psychostimulants include a striatal dopaminergic component. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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